Ageing and senescence
Ageing and senescence
Nov 1, 2022
ox.ac.uk
Cellular senescence is one of the most powerful biological switches influencing aging, metabolic resilience, and disease progression. Decades of research have shown that senescent cells are not just “old cells”—they are metabolically and inflammatory active, reshaping the tissue environment through the SASP (senescence-associated secretory phenotype) and driving many chronic conditions we see in clinical practice. Cellular senescence can be initiated by several mechanisms, one of which is mitoch
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