Nov 25, 2024 · LY3954068 is a small interfering RNA (siRNA) that targets expression of the microtubule-associated binding protein tau. No information is available about the makeup of …

Feb 6, 2024 · Hyperphosphorylated tau polymerizes into paired helical filaments, which aggregate to form neurofibrillary tangles, one of the defining lesions of Alzheimer’s disease. Recognizes …

4 days ago · Phosphorylated tau isn’t just pathological junk; it helps the brain defend against viral infections. So claim scientists led by Rudolph Tanzi and William Eimer at Massachusetts …

May 1, 2025 · They accumulated hyperphosphorylated tau in their brains and lost synapses by approximately 15 months of age, but they had no tau oligomers capable of seeding …

Feb 7, 2024 · This monoclonal antibody, generated against paired helical filaments (PHFs) isolated from Alzheimer’s brains, recognizes tau phosphorylated at serine 202. Recognizes tau …

Feb 1, 2023 · Secondary outcomes include brain tau deposition as per PET, the iADRS, ADASCog14, and ADCS-iADL measures of cognition and function, plus the MMSE. The trial, …

Feb 5, 2024 · PHF-1 reacts with tau phosphorylated at serine-396 and serine-404. Western blot of recombinant human tau phosphorylated in vitro with GSK3β, probed with PHF-1. WT, wild …

Aug 2, 2024 · Background ADEL-Y01 is a humanized IgG1 monoclonal antibody that binds tau protein modified by acetylation at lysine residue 280. Tau acetylation at lysine residues is …

Sep 3, 2025 · As originally described, the hemizygous animals express human tau at levels comparable to endogenous murine tau, whereas homozygotes express human tau at …

Jul 16, 2025 · Two studies analyzed tau-PET scans from thousands of participants in dozens of cohorts. Tangle prevalence increased with age among cognitively normal people, but …