Tau (AT8); Phospho Tau (Ser 202, Thr 205) - ALZFORUM
Feb 6, 2024 · Hyperphosphorylated tau polymerizes into paired helical filaments, which aggregate to form neurofibrillary tangles, one of the defining lesions of Alzheimer’s disease. Recognizes paired …
Triple Trouble: New Knock-in Turbocharges Tauopathy
May 1, 2025 · They accumulated hyperphosphorylated tau in their brains and lost synapses by approximately 15 months of age, but they had no tau oligomers capable of seeding aggregates. …
Tau (PHF-1) | ALZFORUM
Feb 5, 2024 · PHF-1 reacts with tau phosphorylated at serine-396 and serine-404. Western blot of recombinant human tau phosphorylated in vitro with GSK3β, probed with PHF-1. WT, wild-type tau; …
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Cell-Based Assay Matches Tau Strains to Neuropathological Diagnosis
Jan 30, 2025 · Tau, Incorporated. A library of tau mutants generated by alanine substitution (red residues, left), was transduced into biosensor cell lines containing pre-existing tau fibril strains. The …
ApoE3 Christchurch Clings Tightly to Tau, Averting Tangles
Feb 1, 2025 · To find out, the scientists turned to surface plasmon resonance, a technique that quantifies molecular interactions in real time. It showed that ApoE3Ch clings onto tau monomers …
Large Tau-PET Studies Confirm: Tangles Foretell Decline
Jul 16, 2025 · Two studies analyzed tau-PET scans from thousands of participants in dozens of cohorts. Tangle prevalence increased with age among cognitively normal people, but decreased among those …
Tau (CP-13) - ALZFORUM
Feb 7, 2024 · This monoclonal antibody, generated against paired helical filaments (PHFs) isolated from Alzheimer’s brains, recognizes tau phosphorylated at serine 202. Recognizes tau phosphorylated at …
New Role for Tau: Making Lipid Droplets in Glia? | ALZFORUM
Oct 22, 2024 · Tau plays an essential role in the production of these droplets, according to a paper in the October Nature Neuroscience. Using a combination of fly and mammalian cell models, scientists …
Could “Big Tau” Protect Brain Regions from Tangles?
Sep 12, 2024 · A big tau variant is found in tangle-resistant brain regions such as the cerebellum. This isoform degrades quickly and resists phosphorylation and aggregation. In AD patients, big tau …