About one-fourth of recurrent estrogen receptor-positive (ER+) breast cancers lose ER expression, which renders them resistant to endocrine therapy and able to grow uncontrolled. A team of researchers ...

“It used to be that for a long time, we thought that type 2 diabetes was just your insulin not working — insulin resistance,” says Feroz Papa, MD, PhD. “But that’s only partly the case. Insulin ...

When improperly folded proteins build up in the endoplasmic reticulum (ER), cells become stressed and conditions such as type 2 diabetes, neurodegenerative disorders, and cancers can develop. In a ...

The current pandemic of coronavirus disease 2019 (COVID-19) has spurred intense interest into the mechanisms of cell damage and tissue death following infection by the severe acute respiratory ...

The endoplasmic reticulum (ER) of columella root cap cells has been postulated to play a role in gravity sensing. We have re-examined the ultrastructure of columella cells in tobacco (Nicotiana ...

Triple therapy approach that hits cancer from multiple angles at once could be a game-changer against breast cancers that no longer respond to hormone treatment.

Antibody drug conjugates treatment response score (ADC TRS) for sequencing trastuzuamb deruxtecan (T-DXd) and sacituzumab govitecan (SG) in advanced breast cancer (aBC). Overall survival in patients ...