Toll-like receptor 5 (TLR5) is a membrane-bound sensor of the innate immune system that detects flagellin, a conserved protein component of bacterial flagella. Upon flagellin recognition, TLR5 ...

A team from the University of Bonn and the Research Center Borstel, Leibniz Lung Center (FZB) has discovered a previously ...

The innate immune system employs inflammasomes—intracellular multiprotein platforms—to detect microbial motifs and danger signals, triggering rapid inflammatory responses. Upon sensing perturbations ...

A team from the University of Bonn and the Research Center Borstel, Leibniz Lung Center (FZB) has discovered a previously unknown mechanism of action for a synthetic peptide that mitigates excessive ...

Scientists generally agree that eukaryotes, the domain of life whose cells contain nuclei and that includes almost all multicellular organisms, originated from a process involving the symbiotic union ...

The innate immune system is the body's first line of defense against pathogens and foreign substances. An essential component of this system are pattern recognition receptors, which recognize non-self ...

Secondary infections caused by bacteria or viruses during hospital care remain a long-standing global challenge, despite advances in modern medicine. In particular, mixed bacterial–viral infections in ...

Researchers have shown that innate immune training, also known as trained immunity (TRIM), leads to aggravated bone loss in experimental models of periodontitis and inflammatory arthritis. Clinical ...

Cancer immunotherapy, which primes the body's immune system to fight off tumors, has historically focused on harnessing T cells' natural ability to recognize and attack cancer cells. While this ...