The body's cells change their shape to close gaps such as wounds – with part of the cell flexing depending on the curve of the gap and the organization of cell-internal structures, a new study reveals ...

Yeast, worms, and mice remodel their endoplasmic reticulum early in the aging process. The protective shift offers potential targets to extend healthy lifespan.

When improperly folded proteins build up in the endoplasmic reticulum (ER), cells become stressed and conditions such as type 2 diabetes, neurodegenerative disorders, and cancers can develop. In a ...

About one-fourth of recurrent estrogen receptor-positive (ER+) breast cancers lose ER expression, which renders them resistant to endocrine therapy and able to grow uncontrolled. A team of researchers ...

Improvements in public health have allowed humankind to survive to older ages than ever before, but, for many people, these added golden years are not spent in good health. Aging is a natural part of ...

Janelia researchers have uncovered a novel way that two of the structures inside cells—the endoplasmic reticulum (ER) and lysosomes—coordinate the production of proteins, highlighting how interactions ...

For the first time, researchers have directly visualized how newly formed cellular organelles leave the endoplasmic reticulum (ER) and transition onto microtubule tracks inside living cells. This new ...

According to “Global Cancer Statistics- 2022”, colorectal cancer (CRC) ranks third in incidence and second in cancer-related mortality. Given that approximately 50% of cases progress to metastasis and ...

A collaborative French–Swiss study reveals a previously unknown role for astrocytes in the brain's information processing. Published in the journal Cell, the research shows that these glial cells are ...