“It used to be that for a long time, we thought that type 2 diabetes was just your insulin not working — insulin resistance,” says Feroz Papa, MD, PhD. “But that’s only partly the case. Insulin ...
When improperly folded proteins build up in the endoplasmic reticulum (ER), cells become stressed and conditions such as type 2 diabetes, neurodegenerative disorders, and cancers can develop. In a ...
In a study published in the journal Nucleic Acid Research, a research team at Karolinska Institutet has performed a ...
The current pandemic of coronavirus disease 2019 (COVID-19) has spurred intense interest into the mechanisms of cell damage and tissue death following infection by the severe acute respiratory ...
About one-fourth of recurrent estrogen receptor-positive (ER+) breast cancers lose ER expression, which renders them resistant to endocrine therapy and able to grow uncontrolled. A team of researchers ...
De novo cholesterol biosynthesis is a key metabolic vulnerability in rhabdomyosarcoma. Its inhibition halts cell proliferation and triggers ER stress-induced apoptosis, offering a promising ...
This is a preview. Log in through your library . Abstract Cells of onion and garlic root tips were examined under the electron and phase contrast microscopes after fixation in KMnO4. Special attention ...
A phase II study of S-1 and concurrent thoracic radiotherapy (TRT) for elderly pts with locally advanced non-small cell lung cancer (LA-NSCLC): Okayama Lung Cancer Study Group trial 0801. This is an ...
Antibody drug conjugates treatment response score (ADC TRS) for sequencing trastuzuamb deruxtecan (T-DXd) and sacituzumab govitecan (SG) in advanced breast cancer (aBC). Overall survival in patients ...
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