A team of researchers at VCU Massey Comprehensive Cancer Center has identified a new pathway through which mutations in the tumor suppressor p53 gene—found very frequently in human tumors—hijack DNA ...

Your height may come with a hidden advantage. Being tall has its perks, from reaching the top shelf to seeing over crowds, ...

Clinically available KRAS inhibitors mainly target G12C, which is rare in PDAC and often acquires resistance. Oncogenic KRAS inactivates RB1 via CDK4/6, while RB1 mutation is rare. Thus, CDK4/6 ...

Researchers at Cardiff University have uncovered how a particularly severe form of DNA damage arises—shedding new light on mutation processes that contribute to cancer and inherited genetic conditions ...

A genetic mutation that helps animals like yaks and Tibetan antelopes survive at high altitudes may hold the key to repairing nerve damage in conditions such as cerebral paralysis and multiple ...

Scientists identify a high-altitude genetic mutation in yaks that produces ATDR, a Vitamin A metabolite that repairs myelin damage in MS and cerebral paralysis.

In people destined to get Alzheimer's in their mid-40s, one protein can delay the onset of the disease by about 20 years.

That superhero is a gene called TP53, and for decades scientists have known it as the “guardian of the genome.” In a healthy cell, TP53 acts like both a brake and an emergency stop button. When DNA ...

By Tarun Sai Lomte Scientists reveal how evolution within our own tissues can drive disease, protect cells, and uncover hidden therapeutic targets for future precision medicine. Somatic genomics ...

Many of us might reach for the hair dye the moment those first grey hairs appear. But a new study suggests we may be covering up one of the body's most ingenious defences against cancer.

IU researchers have linked an age-related blood condition to inflammatory bowel disease (IBD) and identified a potential treatment to reduce the severity of inflammation-driven diseases.

Now, a step forward in genetic testing could help doctors look deeper than ever before to predict a patient's future health. In a series of studies published recently in Bone Marrow Transplantation, ...