A pioneering study has revealed that increased stiffness in the extracellular matrix (ECM) of spinal discs impairs energy production in nucleus pulposus cells (NPCs), a key factor in ...

Zhang Sheng, PRECONDITIONING OF THE STIFFNESS MATRIX OF LOCAL REFINED TRIANGULATION, Journal of Computational Mathematics, Vol. 12, No. 2 (April 1994), pp. 113-117 ...

Now, researchers at the University of Tsukuba have identified the roles of matrix stiffness and mechanotransduction in cardiac reprogramming, showing that matrices with softness comparable to ...

This study investigated the effect of ECM stiffness on breast cancer cells. They revealed that the extracellular cell matrix stiffness mediated drug resistance of breast cancer cells via EGFR pathway.