How many ways can a troponin assay come up with a false positive or a false negative? In this episode of AP Cardiology, Andrew Perry, MD, tallies it up with Robert Christenson, PhD, of the University ...

Interference in laboratory assays is a concern since it can positively or negatively influence test results, which can affect patient care. Interferents could be endogenous or exogenous compounds.

Luminescence and fluorescence-based assay methods prevail in modern HTS. Although invaluable as technologies, the problem of compound-related assay interferences such as quenching, auto-fluorescence, ...

Avoiding immunoassay interference requires blockers to be included in every immunoassay. Historically, animal-based interference blockers have been used to improve assay accuracy; however, they are ...

Immunoassays used for human in vitro diagnostics (IVD) often use animal-sourced antibodies to recognize specific disease markers. A small percentage of individuals, however, may have antibodies in ...

The US Food and Drug Administration is reminding the medical community about the potential for high levels of biotin—or vitamin B7—to interfere with certain lab tests, including cardiac troponin ...

High-throughput screening (HTS) is a cornerstone of modern drug discovery, enabling the evaluation of thousands to millions of potential drug compounds. Advances in automation and miniaturization have ...

Increasingly accessible to academic researchers, high-throughput screening (HTS) is one of the best ways to discover starting points for new chemical probes and first-in-class drug candidates. However ...