ARIZONA -- The Arizona Cardinals move into their Week 12 meeting with the Jacksonville Jaguars without two offensive starters, as head coach Jonathan Gannon told reporters Marvin Harrison Jr. and Emari Demercado would not suit up. Harrison had appendix surgery last week. This will be his second game missed due to appendicitis.

The Jacksonville Jaguars are headed to the West Coast to face off against the Arizona Cardinals. The Jaguars and Cardinals have played each other six times. Although the Cardinals have scored only 143 total points, compared to Jacksonville’s 142, they lead the series 4-2.

The San Francisco 49ers face the Arizona Cardinals in Week 11 of the NFL season on Sunday, Nov. 16, 2025 at State Farm Stadium in Glendale, Arizona.

The San Francisco 49ers had huge plays on both sides of the ball to earn a blowout win over the Arizona Cardinals. Here are the highlights.

Some will argue that the Big East configuration, which included UC, Louisville, Pitt, Syracuse and West Virginia, plus the mainstays Connecticut, Villanova, Georgetown, St. John’s, Marquette and Providence, was one of the better basketball conferences. But the Cardinals, Panthers and Orange opted for the ACC and the Mountaineers entered the Big 12.