The diagnosis of cervical dysplasia and carcinoma is based on both the objective evaluation of well-defined microscopic features and on the more subjective analysis of often subtle parameters to ...

A study by Children's Medical Research Institute (CMRI) researchers reveals a new group of proteins that guide the powerful enzyme telomerase, opening potential doors to novel treatments for cancer, ...

Cancer is a significant cause of death worldwide and many efforts have been devoted to the development of methods for early detection. Telomerase are considered as a tumor biomarker for early ...

Human telomerase is a ribonucleoprotein that is minimally comprised of protein (hTERT) and RNA (hTR) components. We have applied single-molecule fluorescence two-color coincidence detection to ...

A central question in molecular biology is how cells protect their chromosomes from damage during repeated cell division. At the heart of this protective process is an enzyme called telomerase. Now an ...

Researchers have published the first detailed picture and description of the 3-dimensional molecular structure of telomerase – a discovery that could enable better targeted drug screening and could ...

Scientists investigate human telomere length to elucidate aging and diseases such as cancer and neurodegenerative disorders. In normal mammalian cells, a small telomeric DNA segment is lost after each ...

Elizabeth Blackburn, Jack Szostak, and Carol Greider were recently awarded the Nobel Prize in Physiology or Medicine for their elucidation of the structure and maintenance of telomeres (the tips of ...

Effects of panobinostat, a novel deacetylase inhibitor, in primary cultures of anaplastic thyroid tumors. Background: Cancer stem cells (CSCs) are established firmly to play a key role in tumor ...