A study led by Qun-Ying Lei shows that PGG inhibits the MAT2A enzyme activity while simultaneously promoting its degradation.

A sum of 921 samples were collected from three independent data sets. We obtained pyroptosis-related genes from both the Molecular Signatures Database and relevant literature sources and used four ...

Body mass index (BMI) as a prelude to hepatocellular carcinoma (HCC) and metabolic dysfunction–associated steatohepatitis (MASH) risk factors in patients with no identified risk factor for developing ...

About 50% of the adult population throughout the world over the age of 70 years has chronic kidney disease (CKD) and renal fibrosis. Both CKD and renal fibrosis begin as pyroptosis, during which a ...

Pyroptosis is a proinflammatory type of cell death that is associated with gasdermin-mediated membrane hole formation, as well as cell enlargement and lysis. Pyroptosis plays an important role in both ...

Promoting pyroptosis—an inflammatory form of programmed cell death—has become a promising treatment strategy for cancer. In research published in The FASEB Journal, investigators purified a long-chain ...

A fiery form of cell death helps trigger regeneration of a critical immune organ after damage, according to preliminary work in mice, presented Dec. 7 by Fred Hutchinson Cancer Research Center ...

Researchers report a new method for analyzing pyroptosis -- the process of cell death that is usually caused by infections and results in excess inflammation in the body -- and show that the process, ...

Chengdu Baiyu Pharmaceutical Co. Ltd. has synthesized NLRP3 inflammasome inhibitors acting as pyroptosis inhibitors reported to be useful for the treatment of cancer, autoimmune, cardiovascular, ...

This schematic shows the cell death pathway called pyroptosis, Greek for going down in flames. When activated by a toxin or an infection, the enzyme caspase-1 initiates several reactions inside of the ...