Proteins are the end products of the decoding process that starts with the information in cellular DNA. As workhorses of the cell, proteins compose structural and motor elements in the cell, and they ...

A new LMU study shows how proteins function reliably even without a stable 3D structure—and the crucial importance not only of short sequence motifs, but also of chemical characteristics. Many ...

This Brush Up is sponsored by Quanterix. Learn more about tau biomarkers and clinical applications. Tau is a flexible protein that stabilizes the internal structure of neurons and supports ...

Malignant melanoma is one of the most dangerous forms of cancer. Around half of melanomas and about 7% of all other cancers ...

A new LMU study shows how proteins function reliably even without a stable 3D structure – and the crucial importance not only of short sequence motifs, but also of the chemical characteristics. Many ...

Proteins carry out most of the work in the cell, and predicting their structure, function and interactions remains one of the ...

A nerve cell resembles a vast tree with branches that communicate with thousands of other cells. To function, it depends on a ...

This fully updated volume explores a wide array of new and state-of-the-art tools and resources for protein function prediction. Beginning with in-depth overviews of essential underlying computational ...

In genetics, one harmful variant can be enough to cause disease—but two can make it far more severe. One notable example is KJ, an infant diagnosed with a rare urea cycle disorder with a grim ...

In the ERC project HelixMold, a team from TU Graz developed a method for the computer-based design of artificial proteins, with a focus on custom biocatalysts for pharmaceutical applications or the ...

Mutations to the protein SPOP are widespread in cancer, yet many remain poorly understood. To address this gap, St. Jude Children's Research Hospital scientists obtained structures of SPOP in both the ...