Learning a new task, mastering a musical instrument or being able to adapt to the constantly changing environment are all possible thanks to the brain’s plasticity, or its ability to modify itself by ...

Researchers have engineered a next-generation glutamate sensor, iGluSnFR4, capable of detecting the faintest incoming ...

This is achieved through recruitment and stabilization of additional glutamate receptors at the synapse over time, leading to a sustained signal through the neuron. In the brains of mice lacking ...

A new protein sensor lets researchers see incoming brain signals, revealing how neurons process information tied to memory ...

A detail of a figure from the paper shows synapses formed between a neuron (above) and muscle (below) a narrow cleft. The distinct T-bar shape indicates an active zone. In the upper image, the synapse ...

A biologically grounded computational model built to mimic real neural circuits, not trained on animal data, learned a visual categorization task just as actual lab animals do, matching their accuracy ...

It has been unclear how to build simulations of entire neural circuits with only measurements from a dead fly’s brain. Using machine learning to combine a wiring diagram with knowledge of the ...

Alzheimer's nerve cells manifest a decrease in the connections between nerve cells, called synapses, shown here within the blue circles. Half the synapse is marked with a red fluorescent stain and the ...

Co-written with Jai Liester. Silent synapses represent one of neuroscience's most fascinating discoveries—connections between neurons that lie dormant until activated by specific triggers. These ...

Comparing models of working memory with real-world data, researchers found that information resides not in persistent neural activity, but in the pattern of their connections. Between the time you ...

Breakthroughs, discoveries, and DIY tips sent every weekday. Terms of Service and Privacy Policy. One of the brain’s most important properties is its flexibility ...

The Noelin family of secreted proteins bind to the external portion of AMPA glutamate receptors and stabilize them on the neuronal cellular membrane, a process necessary for transmission of ...