The guidelines [1] on using methacholine challenge testing (MCCT) to evaluate for airway hyperresponsiveness (AHR), published in 2000, provided a figure that allowed clinicians to calculate ...

For the bronchial provocation test, methacholine was administered by using the five-breath dosimeter method, in which concentrations of 0.025, 0.25, 2.5, 10, and 25 mg/mL were given to the ...