Novel Treatment Targets in Sarcoma: More Than Just the GIST MYC has proven to be a highly potent oncoprotein when it is overexpressed, but is also a pleiotropic transcription factor essential for ...

This is a preview. Log in through your library . Abstract The opposing transcriptional activities of the basic-helix-loop-helix-leucine zipper proteins Myc and Mad, taken together with information ...

The MYC gene family plays essential roles in normal development and in multiple cellular functions. Moreover, aberrant MYC gene activation is profoundly involved in the etiology of a wide range of ...

The MYC oncogene family plays an important role in neoplastic disease, and has been extensively studied over decades. Evidence showing the N-terminal and C-terminal regions of MYC can function as a ...

In healthy cells, the protein MYC helps guide the process of transcription, in which genetic information is converted from DNA into RNA and, eventually, into proteins. However, the shapeless protein ...

Meet MYC, the shapeless protein responsible for making the majority of human cancer cases worse. Researchers have found a way to rein it in, offering hope for a new era of treatments. Meet MYC, the ...

Sperm – in theory, you only need one good one to get the job done. Nevertheless, the average pair of human testicles is estimated to crank out about a trillion of these little cells over a lifetime, ...

The growth protein, MYC, was consistently found with RBM42, which spurs MYC production, in human pancreatic tumors. Above, microscopy for MYC (red) and RBM42 (green) in a representative pancreatic ...

Show More From the Department of Cell & Tissue Biology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA; the Department of Cell & Tissue ...