Nearly 100 years ago, a seemingly simple discovery revolutionized the microscope. The introduction of phase contrast, which garnered a Nobel Prize in 1953, brought into clear view structures inside ...

Over the past two decades, correlative light and electron microscopies (CLEM), have become crucial for deciphering biological complexities across scales. A pivotal aspect of this workflow is the ...

Cryo-electron microscopy (cryo-EM) can help scientists determine the three-dimensional structure of proteins in unprecedented detail. Jacques Dubochet, former group leader at EMBL, shared the 2017 ...

In Nijmegen, Netherlands, researchers have installed the world's first microscope capable of live imaging of biological processes in such detail that moving protein complexes are visible. This new ...

Cellular cryo-ET is a powerful method to study the structure and interactome of macromolecules directly in the cell. To access the cell interior at near-native conditions, cells are vitrified on grids ...

Biohub and UC Berkeley show that the laser phase plate, a revolutionary device with a laser 100 million times brighter than the Sun, dramatically improves images obtained through cryo-electron ...

Advanced light microscopy techniques are giving scientists a new understanding of human biology and what goes wrong in diseases Katarina Zimmer, Knowable Magazine Key takeaways: Super-resolution ...

Berkeley Lab and UC Berkeley physicists' new technique offers detailed images of the small molecules and cell structures that ...

Using a tiny, spherical glass lens sandwiched between two brass plates, the 17th-century Dutch microscopist Antonie van Leeuwenhoek was the first to officially describe red blood cells and sperm cells ...