Researchers from the University of Osaka have demonstrated that mitochondrial hyperfusion, when induced by low levels of DRP1 ...

The innate immune system employs inflammasomes—intracellular multiprotein platforms—to detect microbial motifs and danger signals, triggering rapid inflammatory responses. Upon sensing perturbations ...

Researchers from the University of Osaka have demonstrated that mitochondrial hyperfusion, when induced by low levels of DRP1 ...

The innate immune system relies on intracellular sensor proteins to detect microbial motifs and danger signals. Upon recognition of such stimuli, nucleotide-binding oligomerisation domain-like ...

Distant metastasis and recurrence remain major obstacles limiting the long-term efficacy of immunotherapy for solid tumors, particularly in highly aggressive cancers, such as malignant melanoma.

The concept of trained immunity has redefined innate immune responses as adaptable, durable, and context dependent. Natural killer (NK) cells, traditionally ...

Along with defending against pathogens, the body's innate immune system helps to protect the stability of our genomes in unexpected ways -- ways that have important implications for the development of ...

Scientists discover how innate immunity envelops bacteria. The protein GBP1 is a vital component of our body's natural defense against pathogens. This substance fights against bacteria and parasites ...

Scientists generally agree that eukaryotes, the domain of life whose cells contain nuclei and that includes almost all multicellular organisms, originated from a process involving the symbiotic union ...

Cabozantinib, a drug already used to treat patients with certain types of thyroid or kidney cancer, was able to eradicate invasive prostate cancers in mice by causing tumor cells to secrete factors ...

Secondary infections caused by bacteria or viruses during hospital care remain a long-standing global challenge, despite advances in modern medicine. In particular, mixed bacterial–viral infections in ...