Two junior research groups at Ruhr University Bochum, Germany, have developed a drug complex that kills cancer cells in such ...

Papa believes that during the gradual development of type 2 diabetes, the stress of processing large amounts of insulin within the ER compartments of beta cells can stress the ER. Using new techniques ...

The endoplasmic reticulum (ER) is an organelle that has essential roles in multiple cellular processes that are required for cell survival and normal cellular functions.

The peripheral endoplasmic reticulum (ER) forms a continuous, dynamic network of tubules that plays an important role in protein transport and quality control, cellular signaling, and stress response.

Two junior research groups at Ruhr University Bochum, Germany, have developed a drug complex that kills cancer cells in such a clever manner that they raise a red flag as they die. They signal to the ...

Sepsis-induced immune dysfunction is a major contributor to high mortality rates in septic patients. Recent findings shed light on the role of ...

The UPR was also confirmed to be due to viral infection, mediated by ER stress in these cells. Apoptosis is due to this pathway, as well as by NRF2-mediated signaling.

Significantly, in cells void of Ire1p or Hac1p, and which cannot fully activate the UPR, no ROS accumulations were found. “Our results support a model in which the ultimate phenotype of sustained, ...

Sigma receptors are proteins found on mainly the surface of endoplasmic reticulum (ER) in certain cells. Sigma-1 and sigma-2 are the two main classes of these receptors. The sigma-1 receptor is ...

How breast cancer cells lose their ER. Two cellular proteins known as 14-3-3τ and ERα36 have been previously implicated in the development of breast cancer resistance to endocrine therapy. “Working ...

How breast cancer cells lose their ER. Two cellular proteins known as 14-3-3τ and ERα36 have been previously implicated in the development of breast cancer resistance to endocrine therapy.