San Francisco 49ers WR Skyy Moore sped past the Cardinals coverage unit with a 98-yard kickoff return to open the Week 11 matchup.

The San Francisco 49ers had huge plays on both sides of the ball to earn a blowout win over the Arizona Cardinals. Here are the highlights.

The 49ers (6-3) put the pedal to the metal on a game-altering drive in the second half, running the ball eight straight times, capped by a touchdown run for backup Brian Robinson Jr., who just ran over Giants corner Tae Banks for the score.

The Rams' quarterback had a stellar performance on Sunday, throwing for 280 yards and four touchdowns in their 42-26 win over the 49ers. His second touchdown pass of the day gave him 400 passing touchdowns in his career, making Stafford just the ninth quarterback in NFL history to reach that threshold.

After a frustrating six-week wait to return from injury, 49ers quarterback Brock Purdy didn't take long to get back into a rhythm Sunday, throwing for 200 yards with three touchdowns and no interceptions in a blowout win over the Cardinals.

Week 10 of the NFL season is in the books! It began with a sour start on Thursday night after Broncos quarterback Bo Nix played one of the worst games of his career, yet still led Denver to an ugly 10-7 victory over the Las Vegas Raiders.

Los Angeles Rams running back Blake Corum rushes for 15 yards against the San Francisco 49ers at Levi's Stadium.

Arizona Cardinals vs San Francisco 49ers picks, predictions, odds, win probabilities for NFL Week 11 Sunday game on Nov. 16. Who will win game today?

The New York Giants play host to the San Francisco 49ers on Sunday in a battle of teams missing multiple star players on both sides of the ball.